A free, self-paced textbook in 8 chapters. Read a chapter, then drill it with the 161 companion flashcards using spaced repetition.
Acetaminophen produces analgesia and antipyresis but overdose is dangerous because hepatic CYP2E1 converts it to the toxic metabolite NAPQI, which is normally detoxified by glutath...
Warfarin inhibits vitamin K epoxide reductase, depleting active vitamin K and reducing synthesis of the vitamin K-dependent clotting factors II, VII, IX, and X (mnemonic "1972") al...
ACE inhibitors reduce blood pressure and provide mortality benefit in heart failure and proteinuric kidney disease but produce a recognizable cluster of side effects: dry cough, an...
Insulin preparations are categorized by onset and duration: rapid-acting lispro, aspart, and glulisine; short-acting regular insulin; intermediate-acting NPH; and long-acting glarg...
Aminoglycosides such as gentamicin act via concentration-dependent killing and are limited by nephrotoxicity and ototoxicity, both of which can be reduced by once-daily dosing. Van...
Antidepressants include SSRIs (fluoxetine, sertraline, escitalopram), SNRIs (venlafaxine, duloxetine), TCAs (amitriptyline, nortriptyline, imipramine, clomipramine, doxepin), MAOIs...
Inhaled anesthetic potency is inversely related to the minimum alveolar concentration (MAC), while speed of onset is governed by the blood:gas partition coefficient, with lower val...
Cytotoxic chemotherapy spans several mechanistic classes. Cyclophosphamide is an alkylating agent that crosslinks DNA, with signature toxicities of hemorrhagic cystitis (prevented...